Effect of sensory deprivation and Locus Coeruleus (LC) electrical stimulation on the response properties of layer IV barrel cortex neurons in male rats
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چکیده مقاله:
Introduction: Barrel cortex of rodents is responsible for sensory information processing from muzzle whiskers. Locus coeruleus (LC) as the main source of norepinephrine (NE) in the cortex, is effective on the sensory information processing. Methods: Rats were divided to 2 groups. One group underwent sensory deprivation (P4) and the other group served as control and did not undergo sensory deprivation. Response properties of the neurons were evaluated by extracellular single unit recordings following a controlled mechanical deflection of the principal whisker (spared whisker), or before the simultaneous deflection of principal and adjacent whiskers (trimmed whisker) were assessed. In the P4 group, all whiskers on the left muzzle, except D2, were trimmed every other day for two months. In both groups, LC was electrically stimulated 0, 50, 100, 200, 400 and 800 ms before controlled principal whisker deflection. Response magnitude, latency and CTR index (lateral inhibition index) were assessed. Results: In the P4 group, deflection of the principal whisker without LC electrical stimulation, increased the response magnitude and CTR index, but decreased the response latency compared to the control group. The magnitude of the response of neurons to the principal whisker deflection was significantly different between P4 and control groups, in following of principal whisker deflection in times of LC stimulation showed significant difference only in 50 ms subgroup. In both groups, pro-stimulation differences in CTR index and response latency remained unchanged after LC stimulation. Conclusion: Our data showed that electrical stimulation of LC following sensory deprivation modulates neuronal response properties and changes their response pattern.
منابع مشابه
Effect of phasic electrical locus coeruleus stimulation on inhibitory and excitatory receptive fields of layer V barrel cortex neurons in male rat
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15 صفحه اولeffect of phasic electrical locus coeruleus stimulation on inhibitory and excitatory receptive fields of layer v barrel cortex neurons in male rat
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Introduction: It is believed that Locus Coeruleus (LC) influences the sensory information processing. However, its role in cortical surround inhibitory mechanism is not understood. In this experiment, using controlled mechanical displacement of whiskers; we investigated the effect of phasic electrical stimulation of LC on response of layer V barrel cortical neurons in anesthetized rat. Methods:...
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عنوان ژورنال
دوره 13 شماره None
صفحات 404- 415
تاریخ انتشار 2010-01
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